Periactin Weight Gain: Does Periactin Make You Gain Weight?

Gain Much Needed Weight with Periactin

Periactin is one of several brand name of the drug prescription cyproheptadine.

It’s usually used by doctors to treat any symptoms of seasonal allergies and allergic reactions.

It can also be used to stimulate children and adults appetite in order to gain weight.

Normally, it is being used for some patients who are suffering appetite loss.

Antihistamines such as Periactin are most commonly used in preventing or relieving symptoms of fevers and various kinds of allergy.

The medicine work by avoiding the causes of a matter called histamine that is being produced by our body.

It can cause watery eyes, runny nose, sneezing, and itching.

And also, for others, the histamine can cause the closing of their air passages to their lungs such as bronchial tubes and it makes a person to breathing difficulty.

Some types of antihistamines can also be used to avoid dizziness, vomiting, nausea, and motion sickness.

To patients who have Parkinson’s disease, a medicine called “diphenhydramine” can be used in decreasing tremors and stiffness.

And also, the diphenhydramine which is in a form of syrup can be used in relieving the cough which is the cause of hay fever and cold.

Furthermore, since antihistamines might cause a side effect which is drowsiness, some of the medicine might be used in helping people to fall asleep.

Another brand name for cyproheptadine is called Hydroxyzine, it is used to treat a person’s emotional and nervous condition in order to control a person’s anxiety.

man periactin weight gain

And also it is used by doctors to help their patients go to sleep before any surgery.

Several types of antihistamines are being used to treat patients who have chronic urticaria that is a tireless hive looking rash.

Antihistamines can also be utilized for any other condition if it has been determined by a doctor.

The preparation of antihistamine are available for those who have their doctor’s prescription, but, it can also be purchased OTC (Over-The-Counter).

However, if it is to be used to treat children under the age of 4, it might cause serious side effects. Cyproheptadine is an ideal medicine in order to treat and relieve a migraine, itching, and allergies.

How does Periactin work?

As mentioned earlier, Periactin or Cyproheptadine is a type of an oral antihistamine and commonly used as a treatment for allergic reactions by blocking the harmful effects of histamine which will be released by all the cells in our body during various form of allergic reaction or viral infection such as common cold, and is known as the first predecessor of antihistamine.

Increased production of mucus, sneezing, and itching is the common causes when changes are stimulated in the cells by histamine binding on the other cells.

With the help of Periactin, it competes as well as preventing the histamine for the cell receptors then bind itself towards the receptors even without stimulating changes in the cells.

It also prevents drowsiness by blocking ant actions of the two neurotransmitters used for muscle and nerve’s communication, the anticholinergic effects and serotonin.

Steps on Taking Periactin in Gaining Weight

step by step

Step #1

Set an appointment with your physician or doctor in order to determine if the medicine Periactin is an ideal option for helping you to gain some weight.

Make sure that your physician or doctor has a record of all the medication that you normally take, and this includes OTC medications and herbal supplements as they might not be congruent with Periactin supplement.

And make sure that the doctor has your list of medical history so that the doctor can prescribe you the proper dosage.

But, if you are experiencing heart disease, hyperactive thyroid, enlarged prostate, glaucoma, high pressure, asthma attacks, and stomach ulcers, you might not be suited to consume Periactin supplement or you might need to ask your doctor to adjust your dosage.

Step #2

Fill up your prescription at any pharmacy in purchasing the Periactin supplement.

But if you’ve never taken this kind of supplement, then might as well ask your doctor or the pharmacist for the right dosage instruction for further understanding on taking the supplement.

Step #3

Take the Periactin supplement based on the dosage instruction which is listed in the prescription bottle.

It should normally be taken about 2 to 3 times each day according to the notes of PubMed Health. It is either prescribed in a liquid or pill form.

If you’ve been prescribed with the supplements liquid form, it is important to use the cup provided in the medication for you to measure the supplements like a kitchen spoon, however, the measuring cups that are provided will not always be as accurate as an ordinary spoon.

Make sure that you take Periactin and at the same time consume a glass full of liquid.

Step #4

Always pay attention to the feeling you sense after taking the Periactin supplement.

The potential side effect involves insomnia, drowsiness, upset stomach, and dry mouth.

It’s also possible for you to experience an allergic reaction when taking a Periactin supplement.

The symptoms of an allergic reaction involve oral or facial swelling, hives, and difficulty in breathing.

Step #5

Eating healthy foods regularly when taking a Periactin supplement is highly suggested.

It might be tempting for you to eat junk and unhealthy foods for you to gain some weight, however, your aim is to increase weight in a healthy way.

Dairy products, lean sources of protein, beans, vegetables, whole grains, and fruits are the ideal options to consume in helping you gain healthy weight.

Step #6

You must drink sufficient amount of water while taking a Periactin supplement.

It is highly important for you not to get thirsty.

Because if you get thirsty, it is a sign that you’re slightly dehydrated. Milk, fruit juice, and water are the ideal options to consume.

Remind yourself to not drink sodas or any other sugary drinks as they might not help you rehydrate.


The dosage of medicines in the list below will not be the same for every patient.

Always follow the doctor’s instructions or look for the directions which are on the label of the supplement.

The information seen below involves only all the average dosage of various supplements.

If your dosage is different, then do not replace it unless the doctor instructs you to.

Depending on the power or strength of your supplement it determines the amount that you must take.

And also, the number of dosages that you consume every day, the interval between every dosage, and the span of time that you consume the supplement will depend on your medical condition for which you’re using the supplement.

For antihistamine use purposes:

For azatadine

  • Oral dosage tablet form:
    • For adults – take one to two milligrams every 8 to 12 hours as required.
    • For children’s aged 12 years and above – take 0.5 milligrams to 1 milligram 2 times each day as required.
    • For children’s aged four to twelve years old – the dosage and proper use must be verified by the doctor.
    • Children and toddlers aged four years old – use of the supplement is not suggested.

For brompheniramine

  • Oral dosage liquid, tablets, or capsules form for regular or short-acting:
    • Grownups and teenagers – must take four milligrams every 4 to 6 hours as required.
    • Children’s aged six to twelve years old – must take 4 milligrams every 4 to 6 hours as required.
    • Children’s aged four to six years old – must take one milligram every 4 to 6 hours as required.
    • Children and toddlers aged four years old – use of the supplement is not suggested.
  • For injection dose form:
    • Grownups and teenagers – must take ten milligrams injected into a muscle part, under your skin, or in a vein for every 8 to 12 hours.
    • Children’s aged four to twelve years old – must take 0.125 milligrams per kg or 0.06 milligram per lbs. of your body weight that will be injected to a muscle part, under your skin, or in a vein 3 to 4 times each day as required.
    • Children and toddlers aged four years old – use of the supplement is not suggested.

For cetirizine

  • Oral dosage tablets and syrup form:
    • Grownups – must take five to ten milligrams once each day.
    • Children’s aged 6 years old and above – must take five to ten milligrams once each day.
    • Children’s aged four to six years old – must take 2.5 milligrams once each day.
    • Children and toddlers aged four years old – use of the supplement is not suggested.

For chlorpheniramine

  • Oral dosage liquid or tablets form for regular or short-acting:
    • Grownups and teenagers – must take four milligrams every 4 to 6 hours as required.
    • Children’s aged six to twelve years old – must take two milligrams 3 to 4 times each day as required.
    • Children’s aged four to six years old – dosage and use must be verified by the doctor.
    • Children and toddlers aged four years old – use of the supplement is not suggested.
  • Oral dosage tablets or capsules form of long-acting:
    • Grownups – must take eight to twelve milligrams every 8 to 12 hours as required.
    • Children’s aged twelve years old and above – must take eight milligrams every 12 hours as required.
    • Children’s aged four to twelve years old – dosage and use must be verified by the doctor.
    • Children and toddlers aged four years old – use of the supplement is not suggested.
  • For injection dose form:
    • Grownups – must take five to forty milligrams injected into a muscle group, in a vein, or under your skin.
    • Children’s aged four years old and above – must take 0.0875 milligrams per kg or 0.04 milligrams per lbs. of your body weight to be injected under your skin every 6 hours as required.
    • Children and toddlers aged four years old – use of the supplement is not suggested.

What if I miss the dose?

If you’re suggested to take this medicine on a regular basis, always remember to take the missed dose as soon as you think.

However, if your next dose is close to the time you missed the dose, skip it and go back to your normal time.

It is not advisable to take 2 doses at the same time or extra doses.

Again, do not take more dosage unless told by your doctor or any medical professional.

Which supplements or drugs interact with Cyproheptadine?

The Cyproheptadine or Periactin can add painkilling effects of drugs such as alcohol narcotics, benzodiazepines, and tricyclic antidepressants that are known to cause sedation.


This class of drug is used as anti-anxiety medications such as lorazepam (Ativan), alprazolam (Xanax), Clonazepam (Klonopin), and Diazepam (Valium).


Narcotics are used for pain medications, examples are, acetaminophen and oxycodone (Percocet), Hydrocodone (Vicodin), Hydromorphone with Guaifenesin (Dilaudid), Propoxyphene (Darvon), Codeine.


Are used as antidepressants such as Desipramine (Norpramin), amitriptyline (Endep, Elavil), and Imipramine (Tofranil).

Is Cyproheptadine safe during pregnancy or while breastfeeding?

a girl with her pregnant mother

According to a study conducted in women who are pregnant, it has been shown that no harmful effects are made to the fetus dosing right amount of Cyproheptadine on the first, second, and third trimester’s pregnancy.

However, the researcher doesn’t take away the fact that it might harmful.

Medical professional strongly advised that Cyproheptadine should only be used if it’s clearly needed during the pregnancy.

Here are the things that you need to tell your doctors BEFORE you need to take Cyproheptadine (Periactin):

  • If you have an allergic reaction to Cyproheptadine or any other components of this medicine or any other drugs, foods, or other substances.

    If you experienced allergy signs like hives, rashes, itching, shortness of breath, cough, swelling of the face, wheezing, or any other signs, it is a good idea to seek advice from your doctor.
  • If you have these following health problems: ulcers in your stomach or bowel, enlarged prostate, bowel block, glaucoma, or trouble passing urine.
  • If you’ve taken any antidepressant drugs in the last 14 days such as isocarboxazid, tranylcypromine, phenelzine or any drugs used for treating Parkinson’s disease such as rasagiline or selegiline. It may cause hypertension or high blood pressure.
  • For adults, if you’re on the age of 65 or older.
  • If you are breastfeeding, however, it is not advisable to breastfeed while taking this medicine.
  • Do not give Cyproheptadine to the premature or newborn baby.

Warnings and side effects

There is a possibility that you get an overdose on the supplement, so do not take the supplements more than what your doctor prescribed you.

Hallucinations, fainting, dry mouth, large pupils, confusion, pale skin, and extreme.


Blurred vision, diplopia, and dry eyes are some of the ocular side effect of Periactin overdose due to its anticholinergic properties of the drug.


It can also cause hypertension, tachycardia, and palpitations in the cardiovascular structure.

Nervous system

One of the most common side effects of Periactin is the depression in the CNS (Central Nervous System) that usually results in sedation and drowsiness.

These effects frequently ceased with constant use.

It may also cause motor skill impairment, hallucinations, convulsions, tremor, nervousness, restlessness, and confusion.

Digestive System

Periactin overdose may include intestinal side effects such as dry mouth, constipation, nausea, vomiting, and diarrhea.


The side effects may include dry nose and throat, bronchial secretions thickening, wheezing, and chest tightness.


Other Side effects

The dose of Periactin can be beneficial to those who suffered from anorexia which can help them to gain weight due to the Cyproheptadine properties of Periactin.

It has been found in healthy and thin patients to gain 4kg in their weight in about 56 days with a dose of 12 milligrams of Cyproheptadine or Periactin each day.

It also targets the Genitourinary which may cause side effects such as urinary retention, dysuria, and frequency.

Hematologic and Hepatic side effects such as thrombocytopenia, anemia, and agranulocytosis, however, these side effects are rare and uncommon.

Important Notes:

notes book and phone

  • Always keep your supplement in a dark, dry, and cool place. Keep all medicines away from children as well as pets.
  • Dispose of used drugs to avoid any dosing accident.
  • Cyproheptadine is available in generic form.
  • In order to use this drug, you need a prescription for Periactin from your doctor or other healthcare
  • Take a dose with or without food, if upset in your stomach occurs, consume some food necessarily.
  • If you use overdose or suspects that, You should instant call your poison control center or get medical care right away.
    Be ready to tell or show what drug or medication has been taken, how much dosage, and when it happened.


The Periactin supplement can be used to gain weight by stimulating your appetite, it is an ideal supplement for those who are suffering from appetite loss especially the individuals who suffering from Anorexia nervosa.

However, this type of medicine is mainly used to treat allergies and any itchy sensations.

However, this supplement is a type of drug, and any kind of drugs cannot be sustained for a long time.

If a person wants to gain weight in a healthy and safe way, the best way is for them to use high energy protein milk such as Mass Gainer, Orgain, Pro Gainer, Serious Mass, and other health supplements for healthy weight gain.


Always ask professionals advice.

Tell your doctor and pharmacist about all of the drugs and medicines you intake, it may be your prescription, natural products or vitamins.

Tell also about your health problems and make sure that the medicine you’re using is safe.

Do not start, stop, or change your Cyproheptadine dose or any drug without your doctor’s proper advice.

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